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About this project
Biomarkers of Interferon type I response in patients with neurological diseases.
Show list of needs
Material
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Minimum | Optimum |
|---|---|---|
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Specific laboratory supplies
Purchase of test kits (ELISA bioplex-SIMOA) for the detection of biomarkers in the blood of 40 patients.
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€ 2.000 | |
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Basic laboratory supplies
Purchase of reagents and basic consumables for blood processing of 40 patients.
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€ 500 | |
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Specific laboratory supplies
Purchase of test kits (ELISA bioplex-SIMOA) for the detection of biomarkers in the blood of 80 patients.
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€ 4.000 | |
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Basic laboratory supplies
Purchase of reagents and basic consumables for blood processing of 80 patients.
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€ 1.000 |
Infrastructure
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Minimum | Optimum |
|---|---|---|
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Use of facilities and equipment
Access to facilities and use of equipment for biomarker analysis (plate 1).
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€ 100 | |
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Use of facilities and equipment
Access to facilities and use of equipment for biomarker analysis (plates 1 & 2).
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€ 200 |
Task
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Minimum | Optimum |
|---|---|---|
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Commissions 10%
Commissions to Universidad de Málaga, Goteo 5%, TPV 0,8% y PayPal 3,4% + 0,35 cents/transaction.
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€ 442 | |
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Commissions 10%
Commissions to Universidad de Málaga, Goteo 5%, TPV 0,8% y PayPal 3,4% + 0,35 cents/transaction.
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€ 884 | |
| Total | € 3.042 | € 9.126 |
Necessary
Supplemental
General information
Neurological disorders are the third most common cause of disability and premature death in the EU, and increase with the aging of our population. In fact, in Spain it is estimated that they may affect some 7 million Spaniards. These disorders are diseases of the central and peripheral nervous system, i.e. the brain, spinal cord, cranial and peripheral nerves, autonomic nervous system, nerve roots, neuromuscular plates and muscles. There are more than 600 neurological diseases, with neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease and Parkinson's disease being the most important.
Many of the causes of neurodegenerative diseases are unknown and available medical tests may only be useful in assessing the state of an already affected nervous system. The prognosis of neurodegenerative diseases can be quite serious, among other reasons because there is no way to prevent them and their treatments are ineffective as they are limited to palliating the symptoms and not curing the patient. Therefore, in neurodegenerative diseases, it is of vital importance to establish an early, rapid or predictive diagnosis to control a more favorable evolution and establish the most appropriate personalized treatment.
Our research group has been working on the search for inflammatory biomarkers that allow us to identify the main diseases with neurological involvement (Alzheimer's disease, Parkinson's disease, dementia, addictions, etc.). These biomarkers can be used for early detection of the disease, diagnosis, evaluation of its activity or monitoring the efficacy of its treatments. Recent findings show that type β-interferon (IFN-β) responses are a central element in neuroinflammation associated with neurological disorders, but at the same time are critical for neuronal function. Thus, type I interferon and its activity in the brain are potential targets in the investigation of new biomarkers for these pathologies, obtaining a clear clinical benefit.
Main features and goals of the crowdfunding campaign
Our objective is to identify biomarkers for early diagnosis of diseases such as Alzheimer's, Parkinson's, dementia and cognitive impairment, since they do not exist. For this purpose, we have collections of serum samples from these patients, and their associated clinical data, from the Hospital Regional Universitario de Málaga and the Biobank of Málaga-IBIMA-SSPA. The project includes the publication of the results, their communication and dissemination, as well as their clinical-analytical validation. Finally, clinical practice guidelines will be developed in collaboration with the clinical team of the Hospital.
The project will be developed in 4 milestones:
- Recruitment of patients from the Neurology Department of the Hospital Regional Universitario de Málaga.
- Collect blood samples and obtain the plasmas.
- Measure inflammatory biomarkers with ELISA bioplex and SIMOA technology.
- Create a panel of markers that predict the disease.
- Communication and dissemination of results to society.
Why this is important
Neurodegenerative diseases, which affect the nervous system and cause memory loss, behavioral disorders and cognitive functions, are increasing worldwide as life expectancy increases. Currently, the World Health Organization estimates that there are more than 30 million patients in the world with Alzheimer's disease, with this figure doubling every five years.
This project is motivated by the need to advance in research on neurodegenerative diseases and in the constant search for tools that help early detection of the degenerative process and prevent the loss of cognitive functions (memory and learning).
This project is aimed at patients with neurodegenerative diseases (Multiple Sclerosis, Alzheimer, Parkinson) and their relatives, patient associations, professionals in care centers (hospitals and health centers), scientific community in neurology and mental health, academic community in health sciences, and the general population with higher life expectancy, susceptible to suffer with higher probability of a mental deterioration associated with age.
The research group is a consolidated group of the Biomedical Research Institute of Malaga (IBIMA), formed by a multidisciplinary team (physicians, nurses, psychologists, biologists and biochemists) belonging to the Faculty of Medicine of the University of Malaga and to the Clinical Units of Neurology and Mental Health of the University Regional Hospital of Malaga. The team has a solid track record of more than 25 years backed by very outstanding scientific contributions in the field of neuroscience and mental health.
https://www.ibima.eu/grupo_investigacion/neuropsicofarmacologia/
Social commitment
Health and care
This project is motivated by the need to advance in the research of neurodegenerative diseases and in the constant search for tools that help in the early detection of the degenerative process and prevent the loss of cognitive functions (memory and learning) in the most vulnerable population.
Sustainable Development Goals
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Good Health and Well-Being
Ensuring healthy lives and promoting the well-being for all at all ages is essential to sustainable development.
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Industry, Innovation and Infrastructure
Investments in infrastructure are crucial to achieving sustainable development.
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Reduced Inequalities
To reduce inequalities, policies should be universal in principle, paying attention to the needs of disadvantaged and marginalized populations.